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Watch Intently (1)phenobarbital will reduce the level or outcome of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Intently. Coadministration of fentanyl with CYP3A4 inducers could lead into a decrease in fentanyl plasma concentrations, lack of efficacy or, possibly, growth of a withdrawal syn